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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PHGDH
All Species:
31.52
Human Site:
S293
Identified Species:
49.52
UniProt:
O43175
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43175
NP_006614.2
533
56651
S293
A
S
T
K
E
A
Q
S
R
C
G
E
E
I
A
Chimpanzee
Pan troglodytes
A5A6P1
533
56644
S293
A
S
T
K
E
A
Q
S
R
C
G
E
E
I
A
Rhesus Macaque
Macaca mulatta
XP_001114128
533
56466
S293
A
S
T
K
E
A
Q
S
R
C
G
E
E
I
A
Dog
Lupus familis
XP_849835
533
56527
S293
A
S
T
K
E
A
Q
S
R
C
G
E
E
I
A
Cat
Felis silvestris
Mouse
Mus musculus
Q61753
533
56567
S293
A
S
T
K
E
A
Q
S
R
C
G
E
E
I
A
Rat
Rattus norvegicus
O08651
533
56475
S293
A
S
T
K
E
A
Q
S
R
C
G
E
E
I
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515318
533
55943
S293
A
S
T
W
E
A
Q
S
R
C
G
E
E
I
A
Chicken
Gallus gallus
XP_422226
525
55022
S293
A
S
T
R
E
A
Q
S
R
C
G
K
E
I
A
Frog
Xenopus laevis
NP_001091250
509
53841
N294
A
S
T
E
E
A
Q
N
R
C
G
E
E
I
A
Zebra Danio
Brachydanio rerio
NP_955871
527
55379
A293
A
S
T
K
E
A
Q
A
R
C
G
K
D
I
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609496
332
35216
P123
S
L
A
R
P
V
V
P
A
G
Q
S
M
K
E
Honey Bee
Apis mellifera
XP_001121753
478
51893
D259
H
C
A
G
A
A
L
D
V
F
T
E
E
P
P
Nematode Worm
Caenorhab. elegans
NP_496868
322
34673
I114
A
E
L
T
C
T
L
I
L
S
L
S
R
H
V
Sea Urchin
Strong. purpuratus
XP_001203904
493
51557
E256
A
S
T
V
E
A
Q
E
R
V
A
C
E
I
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04130
624
66436
E370
A
S
T
K
E
A
Q
E
G
V
A
I
E
I
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.8
92.5
N.A.
94.5
94.1
N.A.
82.5
67.5
56.2
60.7
N.A.
35
45
32.6
46.3
Protein Similarity:
100
99.6
99.2
96
N.A.
97
97.1
N.A.
90.2
80.1
71.6
75.9
N.A.
48.2
61.9
45.5
61.5
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
93.3
86.6
86.6
80
N.A.
0
20
6.6
66.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
100
100
100
N.A.
13.3
20
6.6
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
66.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
87
0
14
0
7
87
0
7
7
0
14
0
0
0
80
% A
% Cys:
0
7
0
0
7
0
0
0
0
67
0
7
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
7
0
0
0
0
7
0
0
% D
% Glu:
0
7
0
7
80
0
0
14
0
0
0
60
80
0
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% F
% Gly:
0
0
0
7
0
0
0
0
7
7
67
0
0
0
0
% G
% His:
7
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% H
% Ile:
0
0
0
0
0
0
0
7
0
0
0
7
0
80
0
% I
% Lys:
0
0
0
54
0
0
0
0
0
0
0
14
0
7
0
% K
% Leu:
0
7
7
0
0
0
14
0
7
0
7
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% M
% Asn:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
7
0
0
7
0
0
0
0
0
7
7
% P
% Gln:
0
0
0
0
0
0
80
0
0
0
7
0
0
0
0
% Q
% Arg:
0
0
0
14
0
0
0
0
74
0
0
0
7
0
0
% R
% Ser:
7
80
0
0
0
0
0
54
0
7
0
14
0
0
0
% S
% Thr:
0
0
80
7
0
7
0
0
0
0
7
0
0
0
0
% T
% Val:
0
0
0
7
0
7
7
0
7
14
0
0
0
0
7
% V
% Trp:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _